Review
Application of magnetic techniques in the field of drug discovery and biomedicine
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* Corresponding author: ZM Saiyed zainul_s@yahoo.com
1 Department of Biochemistry, Faculty of Science, M S University of Baroda, Vadodara, India
2 Sun Pharma Advanced Research Centre, Biological Research Division, Akota Road, Vadodara, India
BioMagnetic Research and Technology 2003, 1:2 doi:10.1186/1477-044X-1-2
Published: 18 September 2003Abstract
Magnetic separation technology, using magnetic particles, is quick and easy method for sensitive and reliable capture of specific proteins, genetic material and other biomolecules. The technique offers an advantage in terms of subjecting the analyte to very little mechanical stress compared to other methods. Secondly, these methods are non-laborious, cheap and often highly scalable. Moreover, techniques employing magnetism are more amenable to automation and miniaturization. Now that the human genome is sequenced and about 30,000 genes are annotated, the next step is to identify the function of these individual genes, carrying out genotyping studies for allelic variation and SNP analysis, ultimately leading to identification of novel drug targets. In this post-genomic era, technologies based on magnetic separation are becoming an integral part of todays biology laboratory. This article briefly reviews the selected applications of magnetic separation techniques in the field of biotechnology, biomedicine and drug discovery.