Open Access Open Badges Research

Size dependent heat generation of magnetite nanoparticles under AC magnetic field for cancer therapy

Jun Motoyama12, Toshiyuki Hakata3, Ryuji Kato2, Noriyuki Yamashita1, Tomio Morino1, Takeshi Kobayashi4 and Hiroyuki Honda2*

Author Affiliations

1 Nanotherapy Co., Ltd, 19-11, Kikui 2-chome, Nishi-ku, Nagoya 451-0044, Japan

2 Department of Biotechnology, School of Engineering, Nagoya University, Furo-cho, Chikusa-ku, Nagoya 464-8603, Japan

3 Toda Kogyo Corp., 1-4 Meijishinkai, Otake, Hiroshima 739-0652, Japan

4 Department of Biological Chemistry, School of Bioscience and Biotechnology, Chubu University, 1200 Matumoto-cho, Kasugai, Aichi 487-8501, Japan

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BioMagnetic Research and Technology 2008, 6:4  doi:10.1186/1477-044X-6-4

Published: 20 October 2008



We have developed magnetic cationic liposomes (MCLs) that contained magnetic nanoparticles as heating mediator for applying them to local hyperthermia. The heating performance of the MCLs is significantly affected by the property of the incorporated magnetite nanoparticles. We estimated heating capacity of magnetite nanoparticles by measuring its specific absorption rate (SAR) against irradiation of the alternating magnetic field (AMF).


Magnetite nanoparticles which have various specific-surface-area (SSA) are dispersed in the sample tubes, subjected to various AMF and studied SAR.


Heat generation of magnetite particles under variable AMF conditions was summarized by the SSA. There were two maximum SAR values locally between 12 m2/g to 190 m2/g of the SSA in all ranges of applied AMF frequency and those values increased followed by the intensity of AMF power. One of the maximum values was observed at approximately 90 m2/g of the SSA particles and the other was observed at approximately 120 m2/g of the SSA particles. A boundary value of the SAR for heat generation was observed around 110 m2/g of SSA particles and the effects of the AMF power were different on both hand. Smaller SSA particles showed strong correlation of the SAR value to the intensity of the AMF power though larger SSA particles showed weaker correlation.


Those results suggest that two maximum SAR value stand for the heating mechanism of magnetite nanoparticles represented by hysteresis loss and relaxation loss.