Research

Size dependent heat generation of magnetite nanoparticles under AC magnetic field for cancer therapy

Jun Motoyama^1,2, Toshiyuki Hakata³, Ryuji Kato², Noriyuki Yamashita¹, Tomio Morino¹, Takeshi Kobayashi⁴ and Hiroyuki Honda²

¹  Nanotherapy Co., Ltd, 19-11, Kikui 2-chome, Nishi-ku, Nagoya 451-0044, Japan

²  Department of Biotechnology, School of Engineering, Nagoya University, Furo-cho, Chikusa-ku, Nagoya 464-8603, Japan

³  Toda Kogyo Corp., 1-4 Meijishinkai, Otake, Hiroshima 739-0652, Japan

⁴  Department of Biological Chemistry, School of Bioscience and Biotechnology, Chubu University, 1200 Matumoto-cho, Kasugai, Aichi 487-8501, Japan

BioMagnetic Research and Technology 2008, 6:4doi:10.1186/1477-044X-6-4

Published:	20 October 2008

Abstract

Background

We have developed magnetic cationic liposomes (MCLs) that contained magnetic nanoparticles as heating mediator for applying them to local hyperthermia. The heating performance of the MCLs is significantly affected by the property of the incorporated magnetite nanoparticles. We estimated heating capacity of magnetite nanoparticles by measuring its specific absorption rate (SAR) against irradiation of the alternating magnetic field (AMF).

Method

Magnetite nanoparticles which have various specific-surface-area (SSA) are dispersed in the sample tubes, subjected to various AMF and studied SAR.

Result

Heat generation of magnetite particles under variable AMF conditions was summarized by the SSA. There were two maximum SAR values locally between 12 m²/g to 190 m²/g of the SSA in all ranges of applied AMF frequency and those values increased followed by the intensity of AMF power. One of the maximum values was observed at approximately 90 m²/g of the SSA particles and the other was observed at approximately 120 m²/g of the SSA particles. A boundary value of the SAR for heat generation was observed around 110 m²/g of SSA particles and the effects of the AMF power were different on both hand. Smaller SSA particles showed strong correlation of the SAR value to the intensity of the AMF power though larger SSA particles showed weaker correlation.

Conclusion

Those results suggest that two maximum SAR value stand for the heating mechanism of magnetite nanoparticles represented by hysteresis loss and relaxation loss.